Although other pituitary hormone deficiencies including corticotroph deficiency, hypothyroidism, and hypogonadotropic hypogonadism were significantly associated with increased serum hs-CRP levels, the peak GH response to GHRP-2 was a significant variable for estimating serum hs-CRP levels after adjusting for other pituitary hormone secretions as well as atherosclerotic risk factors, and elevated liver enzymes as possible confounders of serum hs-CRP levels in multiple linear regression analyses. This evidence concerns the gene GH1 and hypopituitarism.