In conclusion, this retrospective study revealed a significant and inverse association between GH secretion and serum hs-CRP levels, independent of atherosclerotic risk factors; metabolic complications of GHD, including obesity and fatty liver; and other anterior pituitary hormone deficiencies in patients with NF-PitNET and RCC. The gene discussed is GH1; the disease is obesity due to melanocortin 4 receptor deficiency.