PLA2G2A and obesity due to melanocortin 4 receptor deficiency: Accordingly, PLA2G2A and PLA2G4A genes were up-regulated by omega-3 polyunsaturated fatty acids supplementation (19, 22), whereas SLC27A2, CNR1, DAGLA, MGLL, FAAH, SLC27A1, and SLC27A2 genes were found to be down-regulated in people living with healthy obesity (22).