ADAM23 and cancer: ADAM23 belongs to a subgroup of three catalytically inactive ADAM (A disintegrin and metalloproteinases) members (ADAM11, 22, and 23), known as “cerebral ADAMs.”5 It is predominantly expressed in proliferative niches of the brain and plays a crucial role in neuronal development, myelination, and differentiation.6,7 Several studies have shown that ADAM23 is downregulated in many types of human cancers, including breast,8–10 head and neck,11 colorectal,12 lung,13 bone,14 ovarian,15 and brain16 cancers.