Considering that ADAM23low astrocytoma cells can travel over longer distances than ADAM23hi cells, we investigate the spatial heterogeneity of ADAM23 in clinical samples using single-cell RNA-seq data set.22 Our analysis revealed that ADAM23 expression is associated with an intratumor compartment of origin: being 2.2-fold downregulated at the invasive front of GBM compared to core GBM cells (Figure 2C, P < .05). This evidence concerns the gene ADAM23 and glioblastoma.