The results of NRG Oncology/RTOG 0837 are consistent with the results observed in 4 randomized, controlled trials of bevacizumab or cediranib in newly diagnosed and recurrent glioblastoma.13,14,24,25 The lack of an overall survival benefit with VEGF inhibitors with different mechanisms of action (VEGF-A ligand sequestration, VEGF receptor tyrosine kinase receptor inhibition) in both the newly diagnosed and recurrent disease settings raises the question of whether these drugs have any role as single agents in the treatment of glioblastoma patients. The gene discussed is VEGFA; the disease is glioblastoma.