IDH1 and astrocytoma (excluding glioblastoma): In an effort to investigate more clinically relevant models, we next studied patient-derived BT257 mutant IDH1 astrocytoma tumors implanted in the rat brain.14,24 As demonstrated in Figure 3A, tumor volumes estimated by T2-weighted MRI showed that BAY-1436032 treatment significantly inhibited tumor growth in treated animals when compared to controls (P-value < .001).