IDH2 and central nervous system cancer: It has been used to detect the elevated levels of 2HG present in mutant IDH gliomas in patients,10–13 animal models,14 and cells.15 It has also been used to identify the broader metabolic reprogramming that occurs as a result of the IDH mutation and 2HG accumulation.15,16 A complementary metabolic imaging method is hyperpolarized (HP) 13C spectroscopy in combination with the dissolution dynamic nuclear polarization (d-DNP) technique,17 which highly enhances the signal-to-noise ratio (SNR) of 13C-labeled compounds.