These include the duration of symptoms before presenting to a surgical emergency <2 days, the presence of fever within 24 hours of presenting to a surgical emergency, a pulse rate >90 beats per minute, TLC >12000 cells/dL, CRP >20 mg/L, appendix diameter >10 mm, modified Alvarado score ≥ 9, and adult appendicitis score ≥ 18. This evidence concerns the gene CRP and appendicitis.