To further test the hypothesis that USP19 loss inhibits HCC progression in response to p53 loss and that this is related to decreased SOAT1 expression, USP19 and SOAT1 expression was examined in human HCCs in The Cancer Genome Atlas database and confirmed that both messenger RNAs (mRNAs) were up-regulated. The gene discussed is USP19; the disease is hepatocellular carcinoma.