EGFR and sarcoma: Conformational changes in growth-related proteins, such as occurs in the oncogenic rat sarcoma (RAS)/epidermal growth factor receptor (EGFR)/neurofibromatosis type 1 (NF1) complexes, and altered PPIs, have been implicated in the oncogenic process, allowing them to interact with alternative protein targets and relay their growth signals in an uncontrolled manner.