FOXO3 and cancer: Thus, multiprotein complexes such as protein kinase B (PKB or AKT)-forkhead box O3a (FOXO3a)-14-3-3, murine double minute 2 (MDM2), P53, and Myc-MYC associated factor X (MAX) complexes have been investigated in several studies and have been shown to affect cancer cell growth and death, however how (and why) alternative interactions occur remains unknown [45, 46].