In the present study, it was found that EGCG upregulated hepatic mRNA transcriptions of mhc-2α and hepcidin. This result was consistent with that EGCG upregulated immune deficiency (IMD) pathway that regulated the expression of antibacterial-peptide gene expression and promoted innate immunity in Kuruma shrimp (Marsupeneaus japonicus) [50, 51]. This evidence concerns the gene HAMP and Immunodeficiency.