It was also shown that Ve1 requires the cascade of signaling genes, such as Enhanced Disease Susceptibility 1 (EDS1), Non-race-specific Disease Resistance 1 (NDR1), NB-LRR Protein Required for HR-Associated Cell Death 1 (NRC1), ACIF, MAPK/ERK kinase 2 (MEK2), and SERK3/BAK1 (Fradin et al., 2009). The gene discussed is BAK1; the disease is glycogen storage disease VI.