From a study of the microenvironment of NASH, Wang et al. [41] found that NETs interacted with naïve CD4+ T cells via TLR4, thus enhancing Treg function-associated genes, such as Tgfb1, Id3, Socs1, and Dusp4, and transforming naïve CD4 T cells into Tregs at the stage of differentiation. The gene discussed is CD4; the disease is metabolic dysfunction-associated steatohepatitis.