As previously reported, tumor-generated IL-8 can attract M-MDSCs and G-MDSC (granulocytic-MDSC) from peripheral blood via CXCR1 and CXCR2, thus facilitating the extrusion of NETs, which can be blocked by the specific CXCR1/2 inhibitor reparixin. The gene discussed is CXCR1; the disease is neoplasm.