Professor Emery Bresnick (University of Wisconsin, USA) opened the session on Lineage and Differentiation, chaired by Jun Wei and Shuquan Rao, with a paper entitled “From human clinical genetics to leukemia predisposition-generating networks.” He discussed a patient with leukemia-predisposition syndrome (deficiency in the transcription factor, GATA-2) with a germline GATA-2 variant that inserts nine amino acids (AAs) between the two zinc-fingers (9 aa-Ins). This evidence concerns the gene GATA2 and leukemia.