TP53 and acute myeloid leukemia: The final plenary session of IFSC2022 concluded with a presentation by Professor Anskar YH Leung, of the University of Hong Kong, China, entitled “Complex interplay between immune microenvironment and malignant hematopoietic cells – the TP53 mutated MDS/AML paradigm.” The TP53 mutation of HSCs and progenitor cells was underscored as being associated with myelodysplastic syndrome and AML (MDS/AML).