For instance, an animal model study reported that feeding with high-cholesterol diets and further producing cholesterol crystals could dysregulate inflammasomes through the activation of the NLR family pyrin domain containing 3 (NLRP3) and interleukin-1 beta (IL-1β) secretion, developing inflammatory bowel diseases (IBDs), and colitis-associated cancer (CAC). The gene discussed is IL1B; the disease is inflammatory bowel disease.