TP53 and Familial prostate cancer: We included the 22Rv1 prostate cancer cell line as this cell line showed the highest FANCI protein expression (Supplementary Figure 1) and in terms of TP53 gene functional status falls between LNCaP and PC-3 cells as 22Rv1 cells harbor a monoallelic TP53 mutation (WT/Q331R), resulting in a relatively low p53 protein expression (33).