Compared to normal tissues, the expression level of PLCB2, TGFA, PLOD2, and TUBB6 was significantly higher in ccRCC tissues, while the expression level of IRF6, TEK, ABCB1, and COL4A5 was significantly lower (Supplementary Figures 2A–H). The gene discussed is TGFA; the disease is nonpapillary renal cell carcinoma.