Compared to normal tissues, the expression level of PLCB2, TGFA, PLOD2, and TUBB6 was significantly higher in ccRCC tissues, while the expression level of IRF6, TEK, ABCB1, and COL4A5 was significantly lower (Supplementary Figures 2A–H). This evidence concerns the gene COL4A5 and nonpapillary renal cell carcinoma.