CK1α expression is altered in response to interferon-γ (19) and is required for the expression of pseudo-Programmed death-ligand 1 (20, 21), an immune checkpoint protein that is often overexpressed in cancer cells to evade immune surveillance (22).CK1α has also been implicated in the regulation of DNA damage response pathways in cancer cells (23, 24) and in mouse embryonic stem cells (25), suggesting a potential role in promoting genomic instability. This evidence concerns the gene CSNK1A1 and cancer.