The researchers discovered a failure to inhibit ES-induced death of non-small cell lung cancer A549 cells and NCIH2030 cells using all known inhibitors of cell death modalities after targeted knockdown of the BCL2-Associated X (BAX) and Recombinant Bcl2 Antagonist/Killer 1 (BAK1) genes. This evidence concerns the gene BAK1 and non-small cell lung carcinoma.