In turn, it facilitates the infiltration of CD8+ T lymphocytes into tumors, decreasing the population of immunosuppressive myeloid-derived suppressor cells (MDSCs) and M2-like tumor-associated macrophages (TAMs), increasing the population of myeloid dendritic cell (mDC) and M1-like TAMs, ultimately improving the inhibitory state of tumor immune microenvironment (12, 15, 26, 27). The gene discussed is CD8A; the disease is neoplasm.