Mechanistically, DDX39B upregulated the expression of FUT3, a type of fucosyltransferases, by regulating mRNA splicing and export, followed by the fucosylation of TGFβR-I, which subsequently enhanced activation of the TGF-β/SMAD signaling pathway to facilitate the invasion and metastasis of CRC (50). This evidence concerns the gene TGFB1 and colorectal carcinoma.