SIRT1 and colorectal carcinoma: EIF4A3 could bind to circ-SIRT1, and circ-SIRT1 overexpression did not affect EIF4A3 expression, but decreased the abundance of EIF4A3 at the mRNAs of the EMT marker proteins N-cadherin and Vimentin, thereby blocking the inhibitory effect of EIF4A3 on EMT and promoting the proliferation and invasion of CRC cells (58) (Figure 7).