EIF4A3 could bind to circ-SIRT1, and circ-SIRT1 overexpression did not affect EIF4A3 expression, but decreased the abundance of EIF4A3 at the mRNAs of the EMT marker proteins N-cadherin and Vimentin, thereby blocking the inhibitory effect of EIF4A3 on EMT and promoting the proliferation and invasion of CRC cells (58) (Figure 7). This evidence concerns the gene VIM and colorectal carcinoma.