In addition, cancer-associated fibroblasts (CAF) secreted exosomes cricN4BP2L2 could bind to EIF4A3 and positively regulate its expression, and subsequently caused the activation of PI3K/AKT/mTOR axis in CRC cells, which promoted CRC cells stemness and oxaliplatin resistance (61) (Figure 7). The gene discussed is AKT1; the disease is colorectal carcinoma.