Nuclear PKM2 functions as a protein kinase and transcriptional coactivator to regulate the expression of oncogenes and glycolytic genes that trigger the Warburg effect (such as c-Myc, GLUT1, LDHA, Cyclin D1, and MEK5), leading to CRC cell proliferation and metastasis (51). This evidence concerns the gene WEE1 and colorectal carcinoma.