SH2B3 and cancer: The most prevalent altered cancer-related genes were CTNNB1 (16%) and ZNRF3 (16%), followed by EGFR (11%), JARID2 (11%), KMT2B (11%), KMT2C (11%), NSD1 (11%), PIK3CA (11%), SH2B3 (11%), and UBR5 (11%) (Figure 1A).