CD68 and neoplasm: However, the low-grade group showed significantly more CD68+ macrophages, including CD68+, CD68+CD163-, CD68+CD163+, CD68+PD-1-, CD68+PD-1+, CD68+PD-L1-, and CD68+PD-L1+ cells, in both the tumor and total region (Figures 2B–E and Figure S2) than the high-grade group.