PIWIL1 and acute lymphoblastic leukemia: In the present study, we first genotyped five SNPs of PIWIL1, rs35997018 C>T, rs1106042 A>G, rs7957349 C>G, rs10773771 C>T, and rs10848087 A>G, and discovered that rs1106042 A>G was related to increased ALL risk, rs10773771 C>T was related to decreased ALL risk, and the other three SNPs were not associated with ALL risk in eastern Chinese children.