Furthermore, a modest correlation was detected between PLAC8 expression and both IPS CTLA4(+)/PD1(+) and CTLA4(-)/PD1(+) subsets, suggesting the potential of PLAC8 as a predictive marker for immunotherapy response in ccRCC patients (Figures 6E-H). This evidence concerns the gene PDCD1 and nonpapillary renal cell carcinoma.