In addition to the specific clinical manifestations caused by high hormone secretion levels in different subtypes of pituitary tumors, such as the round red face seen in CD, acromegaly and gigantism observed in GH PitNETs, we found a significant number of patients presenting with headaches (90/232), visual impairments (75/232), and pituitary hypofunction (28/232). This evidence concerns the gene GH1 and pituitary tumor.