Moreover, emerging evidence suggests that PYCR1 is upregulated and plays a protumor role in several different types of cancers, including non-small cell lung cancer (19, 20), breast cancer (21), gastric cancer (22), colorectal cancer (23), hepatocellular carcinoma (24, 25), prostate cancer (26) and bladder cancer (27). Here, PYCR1 is linked to prostate carcinoma.