By using MDA-MB-231 breast cancer cells deprived of estrogen receptor β(ERβ) or cultured in medium without estradiol to establish the triple-negative breast cancer (TNBC) model, troglitazone treatment has been demonstrated to induce PRODH-mediated apoptosis through activating PPARγ in TNBC. The gene discussed is PRODH; the disease is breast carcinoma.