POU5F1 and familial pancreatic carcinoma: Additionally, chemo-radio-resistance common in pancreatic cancer stem cells was reversed by treatment with cHAb18 which was effected through blockage of CDs44-STAT3 pathway and reduction of transcription factors NANOG, OCT4, and SOX4, rendering the cells sensitive to gemcitabine-cHAb18 combined therapy (44).