HIF1A and hepatocellular carcinoma: CD147 overexpression under hypoxic conditions regulates that of HIF-1α downstream; growth and survival under hypoxia of hepatocellular carcinoma SMMC-7721, HCC-9204, and LX-2 cell lines were shown to be affected by CD147 and HIF-1α expressions whereby hypoxic exposure of HCC-9204, and LX-2 yielded a time-dependent upregulation of HIF-1α which also correlated with that of CD147 (38).