Data analysis from the TCGA and Gene Expression Omnibus (GEO) for the expression of CD147 and genes responsible for aberrant fatty acid metabolism in HCC, as well as in vivo and in vitro studies of SMMC-7721 and MHCC97L cell lines showed that CD147 correlated with, and upregulated sterol regulatory element binding protein 1c (SREBP1c) expression through Akt/mTOR pathway; SREBP1c then activates FASN and ACC1 gene transcription with resultant de novo fatty acid synthesis. Here, SREBF1 is linked to hepatocellular carcinoma.