There are numerous pro-angiogenic molecules involved in angiogenic signaling in cancers, to mention a few are vascular endothelial growth factor (VEGF) which stimulates angiogenesis, vasculogenesis, vascular permeability, and cellular adhesion; matrix metalloproteinases (MMPs) and plasminogen activators crucial for matrix remodeling, release, and activation of growth factors; VEGF receptors (VEGFR) that integrate signals for angiogenesis and survival, as well as fibroblast growth factors (FGF), Tumor Growth Factors (TGF) and platelet-derived growth factors (PDGF) (62). This evidence concerns the gene VEGFA and cancer.