Also, designed doxycycline-inducible lentiviral-coded CD147-CAR regulated by the Tet-On 3G system (LV-Tet-CD147CAR-T), had a doxycycline-dependent increased proliferative and cytotoxic activity of CD4+ and CD8+ T cells against CD147+ HCC cells, both in vitro and in vivo (101). This evidence concerns the gene CD4 and hepatocellular carcinoma.