Interestingly, CD147 upregulates the molecular expression and function of NF-kB (60); in the study of head and neck squamous cell carcinoma (HNSCC) by Yu et al, the CD147 gene was silenced through lentiviral transfection of HN4 and HN30 cancer cells with CD147-Homo-550 (siRNA) (shCD147) with shNC as controls. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.