who used immunohistochemical staining of non-small cell lung cancer (NSCLC) tissues from human patients as well as in vitro study of NSCLC A549 cell lines, CD147 was shown to form a complex with CD98, a cell-membrane heavy chain-light chain heterodimer known to interact with other molecules such as integrins and influence cellular proliferation, migration, and survival (37). This evidence concerns the gene BSG and non-small cell lung carcinoma.