SLC16A1 and cancer: In another in vitro study of pancreatic ductal adenocarcinoma (PDAC), CD147 had a striking influence on several cancer metabolic activities such as lactate co-transportation with MCT1 and MCT4, regulated phenotypic expression of MCT1 and MCT4, and also the regulation of key metabolic enzymes including aldehyde dehydrogenase 1 A3, transglutaminase 2, pyruvate kinase isoenzyme 2, and glucose-6-phosphate dehydrogenase (45).