BSG and melanoma: Disrupted the CD147-MCT1 interaction using anti-CD147 monoclonal antibody (MEM-M6/1) in colon cancer, melanoma cells, and normal fibroblasts; the inhibition resulted in failure of lactate shuttling, ATP depletion, decreased cellular pH and cell death of the cancer cells with no similar effect in normal fibroblastic cell (47), this affirmed the dependence of cancer cell on lactate glycolysis for growth and survival.