BSG and non-small cell lung carcinoma: ADC designed using maytansinoid-based cytotoxic agent emtansine (DM1) linked by the non-cleavable chemical linker SMCC to CD147 antibody HcHAb18 (HcHAb18-DM1) in NSCLC cells both in vitro and in vivo, was shown to be specifically internalized by CD147+ tumor cells, successfully delivering the payload (DM1) and releasing the active metabolites through lysosomal cleavage, leading to cell cycle arrest at G2/M (112, 113).