In the study by Ding W. et al, the insertion of light and heavy genes coding for CD147 antibody (cHAb18) between the HN and F genes of the oncolytic Newcastle disease virus (NDV) by the reverse genetic system to form a recombinant NDV carrying CHAb18 (rNDV-18HL) maintained the same virulence as the wild NDV strain while additionally attained optimal active cHAb18 expression with increased in vitro and in vivo cytotoxic and anti-metastatic activities against HCC SMMC-7721 cell line (106). Here, BSG is linked to hepatocellular carcinoma.