Some known leukemia-associated transcripts such as DUX4 (79), IGH (80), NFYB (81) and MED12L (82) are notably differentially packaged, with DUX4 being more packaged and IGH, NFYB, and MED12L less packaged in the B-ALL EVs we studied. This evidence concerns the gene MED12L and acute lymphoblastic leukemia.