RUNX1 and acute lymphoblastic leukemia: Of these cytogenetic subtypes, the most favorable (low-risk) and most prevalent subtypes for pediatric ALL are ETV6::RUNX1 and hyperdiploidy, while high-risk subtypes such as BCR::ABL1-like and KMT2A, which has low prevalence in pediatric patients > 1 year old, have the worst outcome (6).