Conversely, the top 200 pediatric B-ALL-exclusive EV RNAs showed pathways such as tumor-necrosis factor mediated signaling, choline metabolism in cancer, inositol phosphate metabolic process, platelet alpha granule lumen processes and protein deacetylation (Figure 9B; Supplementary File 4). This evidence concerns the gene TNF and precursor B-cell acute lymphoblastic leukemia.