Prednisone can exert anti-inflammatory, anti-allergic, and immunosuppressive effects by binding to the cytoplasmic glucocorticoid receptor and can be used to treat various allergic diseases, bacterial infections, eczema, systemic lupus erythematosus, exfoliative dermatitis, etc. (16). The gene discussed is NR3C1; the disease is exfoliative dermatitis.