Further mapping of global mTOR and AR occupancies across genomes (i.e., using RNA-seq) of MDA PCa 2b vs. 22Rv1 and C4-2B may further identify the similarity/difference in metabolic rewiring and mTOR/AR/SMARCD1-mediated signaling in AA PCa vs. EA CRPC. This evidence concerns the gene SMARCD1 and posterior cortical atrophy.