The combination of miR-99b-5p (inhibiting AR/AR-V7, mTOR and SMARCD1 levels and their nuclear translocations) and Enz (inhibiting AR/AR-V7 activation) created synergistic effects on suppressing colony forming (with 70-85% decrease in cell densities) in all EA and AA PCa cell lines, including Enz-resistant 22Rv1 (Figure 5C). This evidence concerns the gene MTOR and posterior cortical atrophy.