CXCR6, C-X-C chemokine receptor type 6, is known to be preferentially expressed on CD8+PD-1high exhausted T cells in hepatocellular carcinoma (HCC) and is hypothesized to play a role in recruiting CD8+ T cells into the tumor microenvironment (73). This evidence concerns the gene CXCR6 and hepatocellular carcinoma.