Upregulation of additional genes from the bile acid and peroxisome signaling pathways was also evident in TIL gene and pathway expression analysis, including upregulation of SOD1, ACSL5, FADS2, CAT, DHCR24, SLC27A2, and IDH2 in melanoma TILs compared to pCD8s (Supplementary Figure 2). Here, IDH2 is linked to melanoma.