SOAT1 and acute myeloid leukemia: 2) All analytic approaches (qPCR, WB, drug combination treatments) should be performed in more AML cell lines, with the best scenario in primary patient samples with detailed transcriptome analyses (single-cell or bulk) to broaden the relevance of this study; 3) The activation of JAK/STAT signaling pathways and inhibitory pathways was based on mRNA expression, which warrants further investigation at the protein analytic level; 4) These promising in vitro results should be evaluated for both therapeutic efficacy and potential toxicity in AML patient-derived xenograft murine models in vivo.