TNF and rheumatoid arthritis: Rheumatoid arthritis (RA) is an autoimmune, inflammatory disorder, characterized by polyarticular swelling in synovium tissue which leads to the destruction of articular cartilage.1 RA primarily targets the small diarthrodial joints of the hand and feet.2 Immunological cells like macrophages, T, and B cells are found in synovium and involved in the production of several cytokinins, interleukins (IL-1B and IL-6), and tumor necrosis factor (TNF-alpha) on activation.1 These inflammatory mediators and cytokine production results in progressive inflammation and joint swelling.