TNF and rheumatoid arthritis: Nanoemulgel is a nanoemulsion-based hydrogel that was developed, which shows improved spreadability and can also act as a drug reservoir to control the release of drug.34 Gokhale et al35 formulated and evaluated Quercetin-loaded nanoemulsion based gel for managing RA, the study conducted by using HIG-82 and RAW 264.7 cells showed a strong inhibitory effect on LPS-induced TNF-α production with no toxic effect on synoviocytes and also inhibited complete Freund’s adjuvant induced paw edema in rats.