The results showed that 177Lu-RM2 therapy was considered a safe treatment in terms of radiation safety for both patients and caregivers.88 A promising therapeutic application of 177Lu-DOTA-trastuzumab for the treatment HER-2-breast cancers was reported.91 The planar and SPECT/CT imaging results showed uptake at both the primary as well as the metastatic sites. The gene discussed is ERBB2; the disease is breast carcinoma.