GSK3B and Alzheimer disease: The microglia are the immune cells of the brain, responsible for the production of pro-inflammatory cytokines resulting in neuroinflammation at the central nervous system (CNS).39 GSK-3 also induces neuroinflammation by activating toll-like receptors in monocytes and promoting glial fibrillary acid protein, a useful marker for astrogliosis.40 Thus, the inflammatory responses are overexpressed in AD.41,42 GSK-3β activation promotes the production of tumor necrosis factor-alpha, interleukin-6 (IL-6), IL-1 and also activates the transcription factors STAT3, STAT5, NF-κB signaling.