MAPT and neuroblastoma: Manzamine A (IC50 = 10.2 μM) was shown to be effective in reducing the phosphorylation of tau in a (human neuroblastoma) cell line following treatment, demonstrating its potential to penetrate cells and interfere with tau pathology in neurodegenerative disorders.66 Different -R groups, such as alkyl aryl, alkyl, and aryl, have been used to make benzothiazinones (BTOs).