Wnt5a is overexpressed in RA-FLS, and noncanonical Wnt5a signaling contributes to the aggressive phenotype of RA-FLS via the Wnt/Ca2+ and Wnt/PCP signaling pathways coupling with p38, ERK, and PI3K/AKT signaling [18]. Here, AKT1 is linked to rheumatoid arthritis.