YAP1 and neoplasm: In addition, the YES-associated protein (YAP), which is a transcriptional coactivator in the Hippo tumour suppressor pathway and is overexpressed in many tumors, showed an increase in expression in PDT and 5-ADC/PDT groups treated with 1 J cm-2 but an inhibition of YAP with 2.5 J cm-2 at the evaluated time point.