While human TNBC and renal cell carcinoma (RCC) cells express high levels of CXCR2 ligands including CXCL1 and CXCL2, a lack of CXCR2 expression by activated NK cells can limit their migration towards these tumors (78, 79). Here, CXCR2 is linked to hereditary clear cell renal cell carcinoma.