Apart from tumor and structural cells, various immune cells such as tumor associated macrophages (TAMs), regulatory T-cells (T-regs), myeloid derived suppressor cells (MDSCs) and neutrophils contribute to release of immunosuppressive factors such TGF-β and prostaglandin E2 (PGE2) that inhibit NK cell anti-tumor functions at the tumor site. Here, TGFB1 is linked to neoplasm.