This study establishes that in HPV-positive OSCC, the elevated expression of ΔNp63 in cancer cells favors the recruitment of anti-tumor immune cells, and more specifically the activation of macrophages via the transactivation and secretion of DKK3 that in turn binds to CKAP4 on macrophage membranes and induces the NF-κB pathway. Here, DKK3 is linked to neoplasm.