The number of MRGPRX2+ cells did not correlate with disease severity, disease duration, pruritus, QoL impairment, eosinophil numbers, and serum levels of tryptase, total IgE, substance P, IL-31, eosinophilic cationic protein, and major basic protein (Figure 4). This evidence concerns the gene MRGPRX2 and Pruritus.