In a phase II trial (NCT04231552) (50), patients with advanced rectal cancer received CAPOX combined with PD-1 inhibitor (camrelizumab) after SCRT and reached a higher pCR rate of 46.2% than that of the combination of PD-L1 inhibitor (avelumab) and mFOLFOX6 after SCRT (37.5%) (68). The gene discussed is PDCD1; the disease is rectal cancer.