PD-L1 expression: As the only FDA-approved biomarker for anti-PD-1 therapies, treatments such as cemiplimab-rwlc, pembrolizumab, and atezolizumab may be considered as first-line for patients with advanced/metastatic PD-L1-High NSCLC (63). This evidence concerns the gene CD274 and non-small cell lung carcinoma.