For protection against TB, CD4+ T cell differentiate into four main characteristics (15): (1) T central memory (TCM) cells that are predominantly found in the lymphoid organs and maintain a high proliferative capacity; (2) T effector memory (TEM) cells that are differentiated from TCM cells upon antigen re-exposure and mainly present in circulation and peripheral sites; (3) T tissue-resident memory (TRM) cells that a proportion of TEM cells subsequently remains in the lung; (4) T effector (TEFF) cells that are newly recruited to arrive after infection. This evidence concerns the gene CD4 and tuberculosis.