Pro-inflammatory cytokines such as IL-1β, IL-8, IL-12, TNF-α, IFN-γ, and anti-inflammatory cytokines like IL-4 and IL-10 have dual functions, activating anti-tumorigenic actions of T cells while also participating in tumor malignant transformation, growth, invasion, and metastasis (8). This evidence concerns the gene IL4 and neoplasm.