Compared to the 83.3 Å distance between anti-WT1-HLA-A*02:01 paratope and anti-CD3 paratope in BiTE, the distance between the two paratopes in WT1 TED is 188.0 Å, larger than the reported 140 Å distance between a T cell and a tumor cell deemed as essential for synapse formation and optimal killing of tumor cells (36, 54, 55) (Supplementary Figure 1). Here, WT1 is linked to neoplasm.