CLEC16A is situated between two neighboring genes: CIITA, crucial for MHC Class II expression, and SOCS1, a negative regulator of cytokine signaling and DEXI. The susceptibility sites, CIITA-DEXI-CLEC16A-SOCS1, are common across various autoimmune conditions (104–108). This evidence concerns the gene SOCS1 and Autoimmunity.