INS and diabetes mellitus: If one focuses upon metabolic disease and DM, therapies that improve nutritional intake that can be complemented by pharmaceutical agents to assist with serum glucose homeostasis and insulin resistance may limit periods of hyperglycemia and the complications of hypoglycemia (6, 8, 16, 19–21, 25, 27–29, 49, 167, 175, 176, 370, 377–379).