MAPT and Alzheimer disease: In the nervous system, AMPK can limit stroke damage in animal models of DM (602), reduce tau deposition (463), regulate neuroinflammation (134, 226, 603), reduce Aß brain accumulation (604), block Aß toxicity (605), oversee mitophagy with ULK1 (606, 607) and improve cognition in experimental models with DM and AD (608).