Several studies have shown that elevated antibody responses to certain antigens from EBV are elevated in MS, in particular immunoglobulin G (IgG) responses to the EBNA1380-440 region have a MS odds ratio of approximately 8 and have also been shown to interact with HLA-DRB1*15:01 to increase disease risk further (19, 24, 64). The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.