CD4 and experimental autoimmune encephalomyelitis: Early research established in particular the role of CD4+ T cells which target these antigens due to several observations, such as the presence of CNS-infiltrating CD4+ T cells in MS brain lesions, genetic risk conferred by HLA-DR and HLA-DQ alleles, increased experimental autoimmune encephalomyelitis (EAE) susceptibility of transgenic mice expressing MS-associated HLA class II molecules, and it is likely that CD4+ T cells also contribute to MS pathogenesis via their influence on both adaptive and innate immune processes such as antibody production by B cells and CD8+ T cell maturation.