ANO2 and Epstein-Barr virus infection: Given that EBNA1-specific antibodies have now been reported in several studies to cross-react with multiple human proteins including MBP (discussed later in this review), CRYAB, GlialCAM and ANO2 (68, 69, 139, 146, 153), all of which were found to be elevated in pwMS and were associated with disease, what evidence is that EBV infection may have triggered these responses?