CD8A and Autoimmunity: A further study investigating the role of CD8+ T cells used a mouse model where oligodendrocytes expressed ovalbumin (OVA) and showed that even high numbers of high avidity OVA-specific CD8+ T cells could not induce EAE, and that these cells were in fact deleted from the immune repertoire to prevent autoimmunity under normal non-infected CNS conditions or during peripheral infection with OVA-expressing Listeria bacteria.