HLA-DRB1 and myeloid sarcoma: PLP139-151 is a frequent target of high avidity T cells in MS (45) – most likely due to its exclusion from thymic tolerance mechanisms – but several other encephalitogenic PLP peptides have been identified in humans such as PLP104−117, PLP142−153, PLP184−199, and PLP190−209, all of which can be presented by the MS risk allele HLA-DRB1*15:01 (47, 109).