Additionally, it is very rare to detect antibody responses to ANO2, GlialCAM and CRYAB in individuals without evidence for a prior EBV infection, particularly EBNA1 IgG, indicating that EBV infection may be a prerequisite for the development of these autoantibodies and implying that molecular mimicry may be driving development of these responses. This evidence concerns the gene HEPACAM and Epstein-Barr virus infection.