Subjecting these mice to an MSU-induced peritonitis model and to an LPS-induced sepsis model showed that S194 phospho-mutation reduced IL-1β levels, reduced peritoneal extrudate cell numbers, and conferred higher resistance to sepsis, thus providing compelling evidence for the importance of this serine residue for mouse NLRP3 inflammasome function. Here, NLRP3 is linked to peritonitis.