NUD may manifest as a concurrent cutaneous manifestation in autoinflammatory conditions like Schnitzler syndrome, a rare disorder characterized by generalized exanthema and IgM monoclonal gammopathy, adult-onset Still disease, a rare systemic autoinflammatory disorder of undetermined origin, presenting a triad of persistent fever, polyarthritis, and rash, cryopyrin-associated periodic syndrome (CAPS), and SLE (40). This evidence concerns the gene CD40LG and systemic lupus erythematosus.