Finally, visualization of the active B-cell subsets on FlowSOM also evidenced that IgM+ or IgG+ expresses CD38; there was no difference in the proportion of IgG+CD38+ B cells, but IgM+CD38+ cells are increased in LTB (≈2-fold) and decreased in DS-TB (≈2.6-fold) and DR-TB patients (≈1.3-fold) compared with UC (Figure 2I). Here, CD38 is linked to tuberculosis.