According to the B-cell phenotypes evaluated here, DS-TB and DR-TB share an immune fingerprint, which suggests that some of the characteristics being assessed, such as elevated frequency of total B cells, elevated IgG antibody levels, elevated plasma levels of IFN-γ and IL-10, and relative frequencies of naive and activated B cells, could serve as indicators of TB progression and as players in the pro-inflammatory and anti-inflammatory status of TB patients. This evidence concerns the gene IFNG and tuberculosis.