HAVCR2 and acute myeloid leukemia: Further investigation is required, not only for all the questions that remained unanswered in our limited study (such as the probable role of TIM-3 in lipolysis in the HL-60 cell line, the role of TIM-3 in other aspects of glucose and lipid metabolism, or the effect of TIM-3 on other metabolic pathways), but also to clarify the effect of TIM-3 on the metabolism of other immune cells, other AML subtypes, and primary AML cells, as well as in a co-culture system with other cells (to recreate the bone marrow microenvironment and cellular interactions) and in vivo models and clinical studies.