Moreover, since we confirmed the upregulation of CPT-1A as a result of TIM-3/Gal-9 interaction in AML cell lines in this study, it might be interesting to examine whether TIM-3 is relevant to CD36 (an FA transporter)-positive LSCs, as these cells seem to represent an extraordinary metabolic profile with elevated FAO (75, 76). This evidence concerns the gene HAVCR2 and acute myeloid leukemia.